One of the Greatest Successes of Modern Medicine
Over the past several decades, the practice of organ transplantation has emerged as one of the preeminent successes of modern medicine, but this was not always the case. Less than a hundred years ago, organ transplantation between humans was considered an experimental, ethically complicated procedure, and optimism in the field was limited.
An Average of 95 Transplants are Conducted in the United States Each Day
CURRENT ORGAN SHORTAGE
More than 110,000 Americans Are Currently on the National Waitlist
An experimental procedure only 40 years ago, human-to-human allotransplantation has become so successful and prevalent worldwide that there is now a shortage of available organs. It is estimated that more than 110,000 Americans are currently on the national waitlist, and another is added every 10 minutes. Consequently, there is a substantial and increasing waiting list of patients registered for kidney, liver, and heart transplants when organs become available but little prospect of any increase in the number of donor organs.
Today, 30 People Will Die or Be Removed from the
Waiting List Due to the Inadequate Supply of Organs
Addressing an Unmet Medical Need
Xenotransplantation is the process of grafting or transplanting organs or tissues between members of different species. While xenotransplantation is not a new concept, the continued and growing problem of the unresolvable shortage of adequate numbers of human donors has led to a strong resurgence of interest in xenotransplantation in recent years.
Today, XenoTherapeutics optimizes the live-cells of organs derived from genetically engineered swine for xenotransplantation and reduces the risk of infection and rejection in human recipients. Specifically, xenotransplantation of vital porcine skin transplants minimize mortality and morbidity from preventable infections and fluid loss and can improve outcomes by reducing scarring and improving restoration of normal bodily functions by utilizing the same proven and reliable mechanisms as deceased human donor allograft skin, while minimizing infectious disease concerns and increasing treatment availability.1
Xenotransplants Are Less Prone to
Infectious Disease Risks than Allotransplants
1. Barone AAL, Mastroianni M, Farkash EA, Mallard C, Albritton A, Torabi R, Leonard DA, Kurtz JM, Sachs DH, Cetrulo Jr. CL (2015) Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization. Burns, 41(3):565–574. https://doi.org/10.1016/j.burns.2014.09.003